The uterus influences peripheral plasma renin activity, particularly in pre-eclamptic women who show significantly higher PRA in uterine venous blood.
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May indicate uterine renin contribution in pre-eclampsia; leaves open causal role and therapeutic relevance pending prospective studies.
Summary Plasma renin activity (PRA) was estimated in cubital and uterine venous blood of 29 non‐pregnant, 15 healthy, and 18 moderately or severely pre‐eclamptic women. In some of the pregnant and non‐pregnant patients, significantly higher or lower values of uterine PRA were obtained compared to those in peripheral blood. The most consistent results were found in pre‐eclamptic patients, in whom significantly higher mean PRA in uterine venous blood was found. It was concluded that the uterus influences peripheral PRA in some non‐pregnant as well as in healthy and pre‐eclamptic women, causing higher or lower PRA in uterine venous blood than in cubital blood.
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Kokot et al. (1972) studied this question.
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