January 1, 1972Journal of Clinical InvestigationOpen Access

Renin Activation in the Venous Plasma from the Involved Kidney in the Patient with Renal Hypertension

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Why the study?

Does the involved kidney in unilateral renal hypertension release a renin-activating factor compared to the contralateral kidney?

Population

31 patients suspected of suffering from unilateral renal hypertension, and 5 normal dogs.

Comparison

In vitro measurement of initial rate of… vs Renal venous plasma from the contralateral kidney.

Design

Other

Authors

MSMohinder P. SambhiUniversity of California, Los Angeles CWCharles E. WiedemanVA Sepulveda Ambulatory Care Center

Discussion

Member takes

Implication

May support a local renin-activating factor in unilateral renovascular hypertension; leaves open its diagnostic or therapeutic utility pending validation.

Structured PICO

Does the involved kidney in unilateral renal hypertension release a renin-activating factor compared to the contralateral kidney?

Population

31 patients suspected of suffering from unilateral renal hypertension, and 5 normal dogs.

Intervention

In vitro measurement of initial rate of angiotensin generation with added excess of homologous renin (Plasma Renin Substrate Activity [PRSA]-20 min) and maximal angiotensin generation (PRSA-180 min) in renal venous plasma.

Comparator

Renal venous plasma from the contralateral (less involved) kidney.

Outcome

Angiotensin II equivalents generated per milliliter of plasma (initial rate at 20 minutes and maximal generation at 180 minutes).surrogate

The study suggests the presence of a renin-activating mechanism in the renal venous plasma from the ischemic kidney in patients with renal hypertension, independent of renin substrate concentration.

Limitations

Mechanism may rapidly exhaust itself in vitro
Requires future work using methods of improved sensitivity and specificity
Role of the contralateral normal kidney remains to be elucidated

Cite This Study

Sambhi et al. (1972) studied this question.

synapsesocial.com/papers/6a86de8c24dcec08efbef508 https://doi.org/10.1172/jci106792

View Full Paper

Ask AI

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Implication

May support a local renin-activating factor in unilateral renovascular hypertension; leaves open its diagnostic or therapeutic utility pending validation.

Renin Activation in the Venous Plasma from the Involved Kidney in the Patient with Renal Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Renin Activation in the Venous Plasma from the Involved Kidney in the Patient with Renal Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider