Key result
Chronic adipose inflammation in obesity is linked to insulin resistance, metabolic syndrome, and endothelial dysfunction.
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Design
Review
This review emphasizes the role of low-grade inflammation in adipose tissue as a key driver of metabolic syndrome and atherosclerosis.
The authors analyze insulin resistance, the metabolic syndrome and endothelial dysfunction as consequence of a common antecedent, a low grade inflammation, indicating that in obesity there is a chronically activated inflammatory state of the adipose tissue. Furthermore, the inflammatory signaling is discussed according to the adipose tissue depot, visceral or subcutaneous.
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Wajchenberg et al. (2009) studied this question. Adipose tissue in obesity exhibits a chronically activated inflammatory state that serves as a common antecedent for insulin resistance, metabolic syndrome, and endothelial dysfunction.
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