Key result
Measuring IVP in a total artificial heart shows negative peaks linearly correlate with filling pressures.
Analysis of the interventricular pressure waveform provides a method to estimate filling pressures and blood volume in a moving-actuator total artificial heart, which may facilitate automatic control.
May support preload estimation for automated total artificial heart control; leaves open translation from animal models to clinical devices.
Right and left filling pressures are important parameters in the automatic control of a total artificial heart (TAH) within normal physiologic ranges. Our TAH is composed of a moving actuator, right and left ventricles, and an interventricular space (IVS) enclosed by a semirigid housing. During operation of the TAH, the IVS volume is changed dynamically by the difference between the ejection volume of one ventricle and the inflow volume of the other. We measured the interventricular pressure (IVP) waveform by using a pressure sensor and analyzed the relationship between the IVP and the preload condition. From in vitro and in vivo experiments, we found that the measured filling pressures were linearly related to the negative peak value of the IVP. Additionally, we found that we could use the time interval from actuator start to the positive peak value of the IVP (outflow valve opening) as a useful parameter to estimate the blood filling volume of the diastole ventricle.
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Jo et al. (2000) studied Total artificial heart control. Interventricular pressure (IVP) waveform measurement was evaluated on Relationship between IVP and preload condition. Measurement of the interventricular pressure waveform in a moving-actuator total artificial heart demonstrated that filling pressures were linearly related to the negative peak value of the IVP.
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