Key result
Six courses of plasmapheresis successfully reduced triglyceride levels from 36.64 mmol/l to 8.05 mmol/l and led to complete resolution of eruptive xanthomas.
Why the study?
Does plasmapheresis resolve eruptive xanthomas and normalize triglyceride levels in a patient with severe hypertriglyceridemia?
Case Report (n=1)
No
Does plasmapheresis resolve eruptive xanthomas and normalize triglyceride levels in a patient with severe hypertriglyceridemia?
Plasmapheresis can be an effective treatment for resolving eruptive xanthomas and normalizing triglyceride levels in patients with severe hypertriglyceridemia and multiple comorbidities.
Plasmapheresis may resolve eruptive xanthomas in refractory hypertriglyceridemia; leaves open its role versus standard therapies.
Eruptive xanthomatosis, characterised by yellowish skin papules, is often associated with hypertriglyceridemia and can signal underlying systemic conditions such as uncontrolled diabetes. Here, we present the case of a 47-year-old woman with eruptive xanthomas and severe hypertriglyceridemia. Taking into consideration the multiple comorbidities, including type 2 diabetes, obesity, and a history of acute pancreatitis, the patient was treated with six courses of plasmapheresis, leading to complete resolution of the lesions and normal triglyceride (TG) levels.
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Petkevičius et al. (2025) conducted a case report in Eruptive xanthomas and severe hypertriglyceridemia (n=1). Plasmapheresis was evaluated on Resolution of eruptive xanthomas and triglyceride levels. Six courses of plasmapheresis successfully reduced triglyceride levels from 36.64 mmol/l to 8.05 mmol/l and led to complete resolution of eruptive xanthomas.
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