Key result
An isolated perfusion circuit restores ~86% of explanted human hearts to a functional beating condition.
Explanted human hearts can be successfully restored to a functional beating state on an isolated perfusion circuit, providing a viable model for studying cardiac pathophysiology.
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May advance ex vivo human heart research; leaves open clinical translation pending validation.
Slater et al. (1995) studied Cardiomyopathy (n=7). Isolated perfusion circuit was evaluated on Restoration to a functional condition. An isolated perfusion circuit successfully restored 6 of 7 explanted human hearts to a functional beating condition, maintaining stable pressure generation for a mean of 152 minutes.
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