Key result
Obesity was associated with reduced fibrinolytic activity and increased fibrinogen levels, but had no correlation with platelet count, platelet adhesiveness, or blood clotting time.
Why the study?
Is obesity associated with changes in platelet adhesiveness, coagulation, and fibrinolytic activity?
Is obesity associated with changes in platelet adhesiveness, coagulation, and fibrinolytic activity?
Obesity is associated with prothrombotic changes including reduced fibrinolytic activity and increased fibrinogen, but not with altered platelet adhesiveness.
Answers are grounded in this paper and cite their sources.
Obesity may promote prothrombotic hemostasis via fibrinolysis and fibrinogen; cross-sectional data leave causal and therapeutic implications open.
In a study of 41 fasting subjects it was confirmed that fibrinolytic activity was reduced in obese persons: an increase in fibrinogen was also associated with obesity. There was no correlation between obesity and the platelet count, platelet adhesiveness to glass, the level of serum fibrin degradation products, or the whole blood clotting time in plastic tubes.
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Warlow et al. (1972) studied this question. Obesity was associated with reduced fibrinolytic activity and increased fibrinogen levels, but had no correlation with platelet count, platelet adhesiveness, or blood clotting time.
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