Key result
Mulberry leaf extract and 1-deoxynojirimycin improve cardiac function and reduce fibrosis in diabetic cardiomyopathy mice.
Why the study?
Mulberry leaves are used to prevent diabetes and have shown effects in preclinical models, but the specific active components of mulberry leaf extract required identification.
Does mulberry leaf extract or its active components improve cardiac function and reduce myocardial fibrosis in mice with induced diabetic cardiomyopathy?
Does mulberry leaf extract or its active components improve cardiac function and reduce myocardial fibrosis in mice with induced diabetic cardiomyopathy?
Answers are grounded in this paper and cite their sources.
1-deoxynojirimycin (1-DNJ) is identified as the main active component of mulberry leaf extract that protects against diabetic cardiomyopathy in mice by regulating the TGF β–Smad2/3 pathway.
Mulberry leaves are used in Chinese traditional medicine to prevent diabetes and the preventive and therapeutic effects of MLE have been seen in preclinical models. Herein, mulberry leaf extract (MLE) was analyzed to identify its active components. Ultra-performance liquid chromatography–mass spectrometry revealed that MLE contained 1-deoxynojirimycin (1-DNJ, 5.47%), chlorogenic acid (CA, 1.21%), resveratrol (RESV, 0.39%), scopoletin (Sco, 0.09%), and astragaloside (AS, 0.04%). Mice with induced diabetic cardiomyopathy were treated with MLE or each of its main components for 12 weeks. MLE and 1-DNJ significantly improved cardiac function, body weight, and glucose and lipid metabolism, while reducing myocardial fibrosis. Moreover, 1-DNJ reduced the levels of reactive oxygen species and oxidative stress, inhibited the TGF-β pathway, prevented the expression of α-SMA and Smad2/3, as well as collagen 1 and 3. Collectively, these findings suggest that1-DNJ is the main active component of MLE that protects the diabetic myocardium and regulates the TGF β–Smad2/3 pathway.
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Cao et al. (2021) studied diabetic cardiomyopathy. Mulberry leaf extract (MLE) and 1-deoxynojirimycin (1-DNJ) was evaluated on cardiac function, body weight, glucose and lipid metabolism, and myocardial fibrosis. Mulberry leaf extract and 1-deoxynojirimycin significantly improved cardiac function and metabolism while reducing myocardial fibrosis in mice with diabetic cardiomyopathy.
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