Key result
Combined lung ultrasound and serum ANGPTL4 predicts NRDS prognosis with ~0.94 AUC.
Why the study?
Respiratory distress syndrome threatens neonates' life, prompting investigation into whether lung ultrasound scores combined with serum ANGPTL4 levels predict NRDS severity and prognosis.
Does the combination of lung ultrasound scores and serum ANGPTL4 levels predict the severity and prognosis of neonatal respiratory distress syndrome?
Cohort (n=145)
No
Does the combination of lung ultrasound scores and serum ANGPTL4 levels predict the severity and prognosis of neonatal respiratory distress syndrome?
Effect estimate: AUC 0.938 (95% CI 0.895-0.981)
p-value: p=<0.001
The combination of lung ultrasound scores and serum ANGPTL4 levels improves the assessment of disease severity and prediction of prognosis in neonates with respiratory distress syndrome.
May support combined lung ultrasound and ANGPTL4 assessment in neonatal RDS; leaves open prospective validation before clinical adoption.
Objective: Respiratory distress syndrome threatens neonates’ life. This study probed the predictive value of lung ultrasound scores combined with serum angiopoietin-like protein 4 (ANGPTL4) levels on neonatal respiratory distress syndrome (NRDS) severity and prognosis. Methods: The NRDS group (n = 115) and control group (n = 30) were established. In both groups, lung ultrasound scores and serum ANGPTL4 levels, lung ultrasound scores and serum ANGPTL4 levels of newborns with NRDS of different severity, the risk factors affecting the poor prognosis of NRDS neonates, and the value of serum ANGPTL4 levels combined with lung ultrasound scores in determining the severity and prognosis of newborns with NRDS were analyzed. Results: The NRDS groups had higher lung ultrasound scores and serum ANGPTL4 levels, and lower Apgar scores than the control group; lung ultrasound scores and serum ANGPTL4 levels were higher in the moderate and severe groups than in the mild group, and those were higher in the severe group than in the moderate group (all p < 0.05). The logistic regression analysis showed that high lung ultrasound scores, and high serum ANGPTL4 levels were risk factors for NRDS poor prognosis (OR > 1, p < 0.05), and high Apgar scores are the protective factor for poor prognosis in NRDS neonates (OR < 1, p < 0.05). The area under the curve of lung ultrasound scores combined with serum ANGPTL4 levels to assess the severity and prognosis of NRDS neonates exhibited a higher assessed value than the single test. Conclusion: Lung ultrasound scores and serum ANGPTL4 levels are closely related to the severity and prognosis of NRDS neonates, and the combination of the two improves the assessed value of the severity and prognosis of NRDS neonates. The study provided a reference for the disease severity assessment of NRDS and the prediction of its prognosis.
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Wang et al. (2025) conducted a cohort in Neonatal respiratory distress syndrome (NRDS) (n=145). Lung ultrasound scores combined with serum ANGPTL4 levels vs. Single test (lung ultrasound or ANGPTL4 alone) was evaluated on Prediction of NRDS prognosis (survival vs death) (AUC 0.938, 95% CI 0.895-0.981, p=<0.001). The combination of lung ultrasound scores and serum ANGPTL4 levels accurately predicted the prognosis of neonatal respiratory distress syndrome with an AUC of 0.938.
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