Anterior pituitary growth hormone treatment in rats increased fat catabolism, leading to protein deposition and sparing of dietary proteins.
Growth hormone promotes protein deposition by increasing fat catabolism, as demonstrated in a rat model.
essentially the same picture; an initial depression of the respiratory quotient which was maintained in the case of the free-fed animals but which, in the case of the limit-fed group, rose to the control levels after 50 days of treatment.5. The results are believed to demonstrate that protein deposition in growth-hormone-treated rats can only take place as a result of an increased emphasis on fat catabolism, with a consequent sparing of dietary proteins for deposition in the tissues.As a corollary to this, it has been shown that in limit-fed rats growth ceases when the body stores of labile fat are exhausted.It is suggested that one of the primary effects of growth hormone activity is in the catabolism of fat.I should like to thank Prof. F, G. Young for his encourage- ment and advice, and Miss P. McLean
Greenbaum et al. (1953) studied this question. Anterior pituitary growth hormone vs. Control was evaluated on Respiratory quotient and fat catabolism. Anterior pituitary growth hormone treatment in rats increased fat catabolism, leading to protein deposition and sparing of dietary proteins.