Statistical analyses of influences of biochemical parameters exerted on tissue plasminogen activator activity, antigen and PAI-1 antigen in blood samples.

We determined tissue plasminogen activator (t-PA) activity, antigen, and plasminogen activator inhibitor-1 (PAI-1) antigen levels, and performed the statistical analyses of correlation with biochemical parameters used for physical check up in 81 volunteers hospitalized for healthy examination. Transaminases (GOT, GPT), γ-glutamyl transpeptidase (γ-GTP), zink sulfate turbidity test (ZTT), thymol turbidity test (TTT), leucine aminopeptidase (LAP), lactate dehydrogenase (LDH), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), uric acid (UA), calcium (Ca), creatinine (CRN), fasting blood sugar (FBS) had significant correlation with t-PA activity, antigen, and PAI-1 antigen. A canonical correlation coefficient was significant between the object variables (t-PA activity, antigen, index and PAI-1 antigen) and the explanatory variables (GOT, GPT, TC, TG, CRN, UA, γ-GTP, HDL, FBS). The results suggest that fibrinolytic balance (t-PA, PAI-1) in blood may be affected by the parameters of the liver function, the uricotelic metabolism, the hyperlipidemia, or the hyperglycemia.