Key result
Serum serotonin levels were significantly higher in patients with peripheral arterial disease scheduled for surgery compared to the control group (p=0.024).
Why the study?
Are serum serotonin levels elevated in patients with peripheral arterial disease compared to controls?
Case-Control (n=140)
Are serum serotonin levels elevated in patients with peripheral arterial disease compared to controls?
Plasma serotonin levels are significantly elevated in patients with peripheral arterial disease scheduled for surgery compared to controls, suggesting it may be an important parameter in this condition.
Answers are grounded in this paper and cite their sources.
Serum serotonin–PAD link in this cohort does not alter practice; leaves open biomarker or causal role for prospective validation.
OBJECTIVE: In this study, we aimed to evaluate the relationship of serum serotonin levels, which are supposed to affect vascular function, to peripheral arterial disease. METHODS: This prospective study was performed in 70 patients (57 males, 13 females; mean age 67 ± 13 years) with peripheral arterial disease scheduled for surgery and 70 controls (52 males, 18 females; mean age 58 ± 12 years). RESULTS: The rates of diabetes mellitus and hypertension and the fasting glucose levels were significantly higher in the peripheral arterial disease group (p = 0.001). Total, low-density, and high-density cholesterol, triglycerides, urea, and creatinine levels, and the smoking rate were similar in both groups (p > 0.05). The serotonin levels were significantly higher in patients with peripheral vascular disease scheduled for surgery compared to the control group (p = 0.024). CONCLUSION: The plasma serotonin level is an important parameter in peripheral arterial disease.
No takes yet. Share an insight, caveat, or question.
Şenol et al. (2014) conducted a case-control in Peripheral arterial disease (n=140). Peripheral arterial disease vs. Controls was evaluated on Serum serotonin levels (p=0.024). Serum serotonin levels were significantly higher in patients with peripheral arterial disease scheduled for surgery compared to the control group (p=0.024).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: