Key result
Beta-radiation creates bidirectional conduction block in ~88% of dogs via transmural fibrosis without thrombus.
Why the study?
Does beta-radiation with strontium/yttrium-90 effectively create contiguous, nonthrombogenic linear lesions and conduction block in the canine atrium?
Does beta-radiation with strontium/yttrium-90 effectively create contiguous, nonthrombogenic linear lesions and conduction block in the canine atrium?
Beta-radiation effectively creates contiguous, nonthrombogenic linear lesions with bidirectional conduction block in a canine model, suggesting potential as a novel adjunct to radiofrequency ablation for atrial arrhythmias.
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Beta-radiation may enable nonthrombogenic linear lesions; leaves open translation to human atrial ablation.
Guerra et al. (2004) studied Intact conduction across the cavotricuspid isthmus (n=8). Beta-radiation (strontium/yttrium-90) was evaluated on Bidirectional conduction block. Beta-radiation (25 to 50 Gy) successfully created bidirectional conduction block in 87.5% (7 of 8) of dogs, producing transmural, linear areas of fibrosis without thrombus.
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