Key result
Myocardial viability loss in rabbit hearts reduces paced complex duration ~17% via shortened R-T periods.
Population
20 isolated rabbit heart preparations
Design
Preclinical
Follow-up
5 to 8 hours
Authors
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May mark viability loss in rabbit models; leaves open clinical translation of paced-evoked responses.
Effect estimate: 17% reduction
The R-T shortening of the paced evoked potential is a sensitive measure of myocardial integrity in isolated rabbit hearts.
Economides et al. (1988) studied Isolated animal heart (n=20). Pacing stimulus using a single unipolar platinum electrode was evaluated on Waveform components of the paced evoked response (stimulus-R interval, R-T period, complex duration) (17% reduction). Loss of myocardial viability in isolated rabbit hearts resulted in a significant lengthening of the stimulus-R interval and a dramatic shortening of the R-T period, reducing complex duration by 17%.
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