Key result
Zinc supplementation reduces aortic remodeling, oxidative stress, and inflammation in mice fed a high-fat diet.
Why the study?
Does zinc supplementation prevent high-fat diet-induced vascular inflammation and aortic remodeling in mice?
Does zinc supplementation prevent high-fat diet-induced vascular inflammation and aortic remodeling in mice?
In a murine model of diet-induced obesity, zinc supplementation prevented, while zinc deficiency exacerbated, high-fat diet-induced aortic remodeling, inflammation, and oxidative stress.
Zinc modulation of vascular remodeling in obese mice is hypothesis-generating; leaves open any role in human metabolic vascular disease pending clinical trials.
Obesity has become a common public health problem in the world and raises the risk of various cardiovascular diseases. Zinc is essential for multiple organs in terms of normal structure and function. The present study investigated the effects of high fat diet (HFD) induced obesity on the aorta in mice, and evaluated whether it can be affected by zinc deficiency or supplementation. Four-week-old male C57BL/6J mice were fed HFD with varied amounts of zinc (deficiency, adequate and supplementation) for 3 and 6 months. Results showed that HFD feeding induced a time-dependent aortic remodeling, demonstrated by increased vessel wall thickness, tunica cell proliferation and fibrotic responses, and inflammatory response, reflected by increased expression of inflammatory cytokines (tumor necrosis factor-α and vascular cell adhesion molecule 1). HFD feeding also caused aortic oxidative damage, reflected by 3-nitrotyrosine and 4-hydroxy-2-nonenal accumulation, and down-regulated nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression and function, shown by down-regulation of its downstream antioxidants, catalase, NAD(P)H dehydrogenase (quinone 1), and metallothionein expression. The vascular effects of obesity-induced by HFD was exacerbated by zinc deficiency but significantly improved by zinc supplementation. In addition, down-regulation of Nrf2 function and associated antioxidants expression were also worsened by zinc deficiency but improved by zinc supplementation. These results suggest that HFD induces aortic remodeling, which can be exacerbated by zinc deficiency and improved by zinc supplementation.
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Chen et al. (2016) studied High-fat diet induced obesity and vascular inflammation. Zinc supplementation and zinc deficiency vs. Adequate zinc was evaluated on Aortic remodeling, oxidative damage, and inflammatory response. In mice fed a high-fat diet, zinc deficiency exacerbated aortic remodeling, oxidative stress, and inflammation, whereas zinc supplementation significantly improved these vascular effects.
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