Key result
Liver transplantation is linked to a ~188% increase in TTV DNA prevalence.
Why the study?
Is TT virus associated with liver diseases and does its prevalence change after liver transplantation?
Population
113 carriers of hepatitis C virus, 10 patients with acute liver failure, 11 patients with cryptogenic…
Design
Cohort
Authors
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Increased post-transplant TTV prevalence warrants no practice change; leaves open its role in liver disease or graft outcomes.
Observational (n=334)
Is TT virus associated with liver diseases and does its prevalence change after liver transplantation?
Absolute Event Rate: 46% vs 16%
p-value: p=< 0.01
TTV DNA prevalence increases significantly after liver transplantation, likely due to immunosuppression causing recurrence of low-level viraemia rather than transfusion transmission.
Shang et al. (2000) conducted an observational in Liver disease and liver transplant recipients (n=334). Liver transplantation vs. Pre-transplantation was evaluated on Prevalence of TTV DNA (p=< 0.01). Liver transplantation was associated with a significant increase in TTV DNA prevalence from 16% pre-transplantation to 46% post-transplantation (P < 0.01).
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