Key result
Clopidogrel resistance in ischemic stroke varies by measurement method and ADP concentration, reaching up to ~18%.
Why the study?
What is the rate of clopidogrel resistance in patients with non-cardiogenic ischemic cerebrovascular disease taking clopidogrel?
Population
72 patients with non-cardiogenic ischemic cerebrovascular disease.
Design
Cross-sectional
Authors
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Method-dependent clopidogrel resistance rates in ischemic stroke should not yet guide therapy; leaves open need for standardized assays and prospective validation.
Cross-Sectional (n=72)
No
What is the rate of clopidogrel resistance in patients with non-cardiogenic ischemic cerebrovascular disease taking clopidogrel?
Clopidogrel resistance in ischemic stroke patients varies between 8-18% depending on the measurement method and definition used.
Fukuoka et al. (2011) conducted a cross-sectional in Ischemic stroke (n=72). Clopidogrel was evaluated on Rate of clopidogrel resistance (turbidimetry with ADP 4 μmol/L). In patients with ischemic stroke, the rate of clopidogrel resistance varied from 8.1% to 18.1% depending on the measurement method (turbidimetry vs. screen filtration pressure) and ADP concentration.
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