Why the study?
Does a clopidogrel 300 mg loading dose compared to 7 days of 75 mg daily, with platelet reactivity-guided dose adjustments, reduce cardiovascular events in patients with stable angina undergoing elective PCI?
Does a clopidogrel 300 mg loading dose compared to 7 days of 75 mg daily, with platelet reactivity-guided dose adjustments, reduce cardiovascular events in patients with stable angina undergoing elective PCI?
Clopidogrel resistance is highly prevalent (56%) in patients undergoing elective PCI, particularly those with obesity and hyperglycemia, suggesting a potential role for platelet reactivity-guided dose adjustments.
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High clopidogrel resistance linked to obesity and hyperglycemia cautions against uniform dosing in elective PCI; leaves open whether reactivity-guided adjustments improve outcomes.
Sulimov et al. (2012) studied this question.
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