Key result
Female sex in Parkinson's is linked to ~115% higher orthostatic hypotension rates and worse autonomic impairment.
Why the study?
While gender-specific variations in cardiovascular autonomic responses are documented in healthy individuals, their presence in Parkinson's disease patients remains unclear.
Do cardiovascular autonomic responses differ by gender in patients with Parkinson's disease?
Comparison
Female vs male patients
Design
Observational study
Authors
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May indicate greater autonomic burden in treated females with PD; hypothesis-generating and should not yet change practice.
Observational (n=90)
Do cardiovascular autonomic responses differ by gender in patients with Parkinson's disease?
Absolute Event Rate: 28% vs 13%
Pharmacologically treated female patients with Parkinson's disease exhibit greater cardiovascular autonomic impairment and symptom burden compared to males, highlighting the need for gender-specific management of dysautonomia.
Meksi et al. (2025) conducted an observational in Parkinson's disease (n=90). Female gender vs. Male gender was evaluated on Orthostatic hypotension. Female patients with Parkinson's disease had higher rates of orthostatic hypotension (28% vs 13%) and, when treated, exhibited greater autonomic impairment and symptom severity than males (P=0.02).
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