Key result
Elevated cleaved antithrombin plasma levels are linked to venous thromboembolism.
Why the study?
Does cleaved antithrombin (ATc) serve as a marker for thrombin generation and coagulation system activation in patients with venous thromboembolism?
Case-Control
Does cleaved antithrombin (ATc) serve as a marker for thrombin generation and coagulation system activation in patients with venous thromboembolism?
p-value: p=0.003
Cleaved antithrombin (ATc) is a novel marker for thrombin generation that remains elevated in the circulation for at least 2 weeks following a thromboembolic event.
ATc elevation was associated with VTE; hypothesis-generating as a thrombin generation marker and requires prospective validation before clinical adoption.
A modified form of antithrombin (AT) cleaved at the active site by thrombin (ATc) has been shown to be generated in vivo, corresponding to 1-4% of the circulating AT. An enzyme immunoassay has been developed for measuring ATc following plasma treatment with ammonium sulphate and heat denaturation of native AT. ATc plasma levels were found to be significantly higher (P = 0.003) in patients developing venous thromboembolism when compared to patients without such events or healthy controls (age and sex matched). In addition, ATc levels correlated with thrombin generation markers: thrombin-AT complex (r2 = 0.66, P = 0.005) and prothrombin fragment 1 + 2 (r2 = 0.58, P = 0.018), but, in contrast to both these markers, elevated ATc levels were detected for at least 2 weeks after the thromboembolic event. In conclusion, ATc appears to be a new marker for thrombin generation and overall activation of the coagulation system, having the advantage of being detected in the circulation for a longer period than other thrombin generation markers.
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Lindo et al. (1995) conducted a case-control in Venous thromboembolism. Cleaved antithrombin (ATc) levels vs. Patients without venous thromboembolism or healthy controls was evaluated on ATc plasma levels (p=0.003). Cleaved antithrombin (ATc) plasma levels were significantly higher in patients developing venous thromboembolism compared to matched controls (P=0.003).
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