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This research aims to evaluate the performance of a new assay for measuring thrombin-antithrombin III complexes in plasma.

October 1, 1988Clinical ChemistryOpen Access

Laboratory and clinical evaluation of an assay of thrombin-antithrombin III complexes in plasma.

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Laboratory evaluation reveals thrombin-antithrombin III complexes in plasma linked to DIC and thrombosis, indicating potential diagnostic utility.

This research aims to evaluate the performance of a new assay for measuring thrombin-antithrombin III complexes in plasma.
Compared TAT assay results with established diagnostic criteria for disseminated intravascular coagulation (DIC)
Included measurements from healthy volunteers and patients with DIC and deep-vein thrombosis
Assessed precision and sensitivity of the TAT assay
Healthy volunteers exhibited TAT levels ranging from 0.8 to 5.0 micrograms/L, mean 2.1 micrograms/L.
Increased TAT levels were found in 25 of 41 DIC patients (mean 15.8 micrograms/L).
In 30 of 35 deep-vein thrombosis patients, mean TAT levels were 9.4 micrograms/L.

Hoek et al. (1988) studied this question.

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Laboratory evaluation reveals thrombin-antithrombin III complexes in plasma linked to DIC and thrombosis, indicating potential diagnostic utility.