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January 1, 1990Thrombosis and Haemostasis

D-Dimer and TAT Measurement in Patients with Deep Venous Thrombosis: Utility in Diagnosis and Judgement of Anticoagulant Treatment Effectiveness

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Why the study?

Does D-Dimer and TAT measurement accurately diagnose deep venous thrombosis and judge anticoagulant treatment effectiveness in patients with acute DVT?

Population

39 patients with phlebographically proven acute DVT (34 proximal, 5 calf)

Design

Cohort

Authors

WSWolfgang SpeiserUniversity of ViennaRMR. MallekMedical University of ViennaRKRenate KoppensteinerVascular Medicine

Discussion

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Implication

D-dimer sensitivity may support ruling out early proximal DVT; leaves open test-specific specificity and need for larger validation.

Structured PICO

Does D-Dimer and TAT measurement accurately diagnose deep venous thrombosis and judge anticoagulant treatment effectiveness in patients with acute DVT?

P
Population
39 patients with phlebographically proven acute DVT (34 proximal, 5 calf)
I
Intervention
Measurement of plasma levels of thrombin-antithrombin III-complexes (TAT) and D-Dimer
O
Outcome
Sensitivity and specificity of D-Dimer and TAT measurements in the diagnosis of proximal DVTsurrogate

D-Dimer EIA measurement has high sensitivity for excluding DVT, and both D-Dimer and TAT levels are useful for monitoring the effectiveness of anticoagulant therapy.

Cite This Study

Speiser et al. (1990) studied this question.

synapsesocial.com/papers/6a7cafd7cc6f1443deba628ahttps://doi.org/10.1055/s-0038-1647284
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurement of Plasma D-Dimer for Diagnosis of Deep Venous Thrombosis1989 · 117 citations
  2. 2Thrombin generation in acute promyelocytic leukemia1984 · 141 citations
  3. 3Factors affecting fibrinopeptide-A levels in patients with venous thromboembolism during anticoagulant therapy1982 · 36 citations
  4. 4Measurement of Plasma Fibrin D-Dimer Levels with the Use of a Monoclonal Antibody Coupled to Latex Beads1987 · 83 citations
  5. 5Determination of Human Thrombin-Antithrombin III Complex in Plasma with an Enzyme-Linked Immunosorbent Assay1988 · 540 citations