Key result
Combined measurement of TAT ≥7.0 μg/L and D-dimer ≥3.0 μg/ml demonstrated 84% sensitivity, 96% specificity, and 90% accuracy for diagnosing deep venous thrombosis.
Why the study?
Does the measurement of TAT and D-dimer accurately diagnose deep venous thrombosis in suspected patients?
Observational (n=50)
Does the measurement of TAT and D-dimer accurately diagnose deep venous thrombosis in suspected patients?
Absolute Event Rate: 20.4% vs 3.8%
p-value: p=<0.001
Combined measurement of TAT and D-dimer provides high sensitivity and specificity, making it a highly useful screening tool for acute deep venous thrombosis.
Supports combined TAT/D-dimer testing for DVT screening; leaves open prospective validation before clinical adoption.
Thrombin-antithrombin III (TAT) and D-dimer were measured in 50 patients suspected of deep venous thrombosis (DVT) to assess the usefulness of these indicators in the diagnosis of DVT. DVT was diagnosed by ultrasonography (compression method and Doppler imaging). In patients who were negative for DVT (Group A), TAT was 3.8 +/- 2.36 micrograms/L (mean +/- SD) and D-dimer was 0.7 +/- 0.69 micrograms/ml, whereas in patients diagnosed with DVT (Group B), TAT was 20.4 +/- 19.10 micrograms/L (p < 0.001) and D-dimer was 9.0 +/- 9.21 micrograms/ml (p < 0.001). Thus, Group B had significantly higher levels of both markers. Moreover, 19 of the 23 cases in Group B had acute DVT, with symptoms appearing within 2 weeks of onset. When the cutoff for a positive diagnosis of DVT was set at TAT of 7.0 micrograms/L or more and D-dimer of 3.0 micrograms/ml or more, sensitivity was 84%, specificity was 96%, and accuracy was 90%. Based on these results, we concluded that TAT and D-dimer are extremely useful in screening for acute DVT.
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Sassa et al. (1996) conducted an observational in Deep venous thrombosis (n=50). Thrombin-antithrombin III (TAT) and D-dimer vs. Patients negative for DVT was evaluated on Thrombin-antithrombin III (TAT) levels (μg/L) (p=<0.001). Combined measurement of TAT ≥7.0 μg/L and D-dimer ≥3.0 μg/ml demonstrated 84% sensitivity, 96% specificity, and 90% accuracy for diagnosing deep venous thrombosis.
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