Why the study?
Does warfarin therapy reduce plasma TAT levels compared to baseline in patients requiring anticoagulation?
Population
61 patients receiving warfarin therapy and 12 patients prior to the initiation of warfarin therapy
Comparison
Warfarin therapy vs Patients prior to anticoagulation and normal…
Design
Cohort
Authors
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Warfarin normalized TAT levels in this cohort; supports TAT as potential monitor but hypothesis-generating and should not yet change practice.
Does warfarin therapy reduce plasma TAT levels compared to baseline in patients requiring anticoagulation?
Plasma TAT levels may be a more appropriate index than conventional PT to monitor the optimal range of anticoagulation for hypercoagulable states.
Uchiyama et al. (1992) studied this question.
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