Key result
Among 143 elderly patients with atrial fibrillation, thrombin generation parameters showed up to a fourfold variability in individuals with identical INR values, which was not driven by inflammation.
Why the study?
Is the wide variation in thrombin generation in atrial fibrillation patients with therapeutic INR due to inflammation?
Population
143 elderly patients with atrial fibrillation on warfarin with therapeutic International Normalized Ratio
Design
Cross-sectional
Authors
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Caution against sole INR reliance for warfarin monitoring in elderly AF; leaves open whether thrombin generation assays could refine risk assessment.
Observational (n=143)
Is the wide variation in thrombin generation in atrial fibrillation patients with therapeutic INR due to inflammation?
In elderly patients with atrial fibrillation on warfarin, thrombin generation varies widely despite therapeutic INR, and this variability is not driven by inflammation.
Gatt et al. (2008) conducted an observational in Atrial fibrillation (n=143). International Normalized Ratio (INR) and Thrombin generation (TG) was evaluated on Relationship between INR and calibrated automated thrombogram (CAT) parameters. Among 143 elderly patients with atrial fibrillation, thrombin generation parameters showed up to a fourfold variability in individuals with identical INR values, which was not driven by inflammation.
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