Why the study?
Does the intensity of anticoagulation measured by INR correlate with thrombin generation measured by F1.2 levels in patients with atrial fibrillation?
Population
846 patients with atrial fibrillation participating in the Stroke Prevention in Atrial Fibrillation III study
Comparison
Adjusted-dose warfarin or combination therapy vs Aspirin alone
Design
Cross-sectional
Authors
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INR may not fully capture thrombin generation in older AF patients; leaves open whether F1.2 monitoring refines anticoagulation.
Does the intensity of anticoagulation measured by INR correlate with thrombin generation measured by F1.2 levels in patients with atrial fibrillation?
While INR inversely correlates with thrombin generation (F1.2) in AF patients, significant variability exists, particularly with older patients showing higher thrombin generation at equivalent INRs.
Feinberg et al. (1997) studied this question.
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