Why the study?
Does the measurement of prothrombin fragment F1+2 detect hypercoagulable and hypocoagulable states in patients with DIC or on warfarin therapy compared to healthy subjects?
Population
100 subjects total, comprising 44 healthy subjects, 34 patients with disseminated intravascular coagulation…
Comparison
Measurement of plasma levels of prothrombin… vs Healthy subjects (n=44).
Design
Cross-sectional
Authors
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F1+2 measurement may identify hyper- and hypocoagulable states; hypothesis-generating and requires prospective validation before clinical use.
Does the measurement of prothrombin fragment F1+2 detect hypercoagulable and hypocoagulable states in patients with DIC or on warfarin therapy compared to healthy subjects?
Plasma F1+2 measured by a novel ELISA is a sensitive biomarker for detecting both hypercoagulable (DIC) and hypocoagulable (warfarin therapy) states.
Takahashi et al. (1991) studied this question.
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