Why the study?
Does the measurement of Prothrombin Fragment 1+2 (F 1+2) correlate with increasing intensity of oral anticoagulation (INR) to assess hemorrhagic risk?
Population
132 patients on long-term warfarin treatment covering 8 ranges of anticoagulation from < 1.5 to 9.0 INR
Design
Cross-sectional
Authors
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F1+2 plateau beyond INR 4.0 limits its utility for hemorrhagic risk at high intensities; leaves open prospective validation as a biomarker.
Does the measurement of Prothrombin Fragment 1+2 (F 1+2) correlate with increasing intensity of oral anticoagulation (INR) to assess hemorrhagic risk?
Prothrombin Fragment 1+2 levels plateau at INR > 4.0, suggesting it is not a useful biomarker for assessing hemorrhagic risk in patients on high-intensity oral anticoagulation.
Cattaneo et al. (1998) studied this question.
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