Why the study?
Does the intensity of oral anticoagulation affect the interrelationships of in vivo coagulation activation markers in patients on stable therapy?
Population
Patients on stable long-term oral anticoagulant therapy
Comparison
Oral anticoagulant therapy at varying intensities vs Normal controls
Design
Cross-sectional
Authors
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Anticoagulation intensity alters coagulation marker interrelationships in stable patients; hypothesis-generating for monitoring utility, needs prospective trials.
Does the intensity of oral anticoagulation affect the interrelationships of in vivo coagulation activation markers in patients on stable therapy?
The interrelationship of coagulation activation markers changes with the intensity of oral anticoagulation, suggesting complex underlying mechanisms that require further clinical trials to determine utility for patient monitoring.
Solymoss et al. (1996) studied this question.
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