Key result
The degree of anticoagulation assessed by thrombotest showed a significant positive relationship with thrombin activity measured by fibrinopeptide A (p<0.001).
Why the study?
Does the degree of anticoagulation induced by acenocoumarol correlate with thrombin activity in patients on long-term therapy?
Population
28 patients who had been on oral anticoagulation with acenocoumarol for at least 1 year.
Comparison
Oral anticoagulation with acenocoumarol vs Different degrees of anticoagulation
Design
Cohort
Authors
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Deep anticoagulation may be required to suppress thrombin activity; leaves open optimal acenocoumarol intensity for long-term use.
Observational (n=28)
Does the degree of anticoagulation induced by acenocoumarol correlate with thrombin activity in patients on long-term therapy?
p-value: p=<0.001
A significant decrease in thrombin activity, as measured by fibrinopeptide A, may be achieved only with deep oral anticoagulation.
Marongiu et al. (2009) conducted an observational in Patients on oral anticoagulants (n=28). Degree of anticoagulation (thrombotest) vs. Different thrombotest ranges was evaluated on Thrombin activity measured by fibrinopeptide A (p=<0.001). The degree of anticoagulation assessed by thrombotest showed a significant positive relationship with thrombin activity measured by fibrinopeptide A (p<0.001).
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