Why the study?
Does the intensity of oral anticoagulation (measured by INR) correlate with markers of coagulation activation (prothrombin fragment 1+2, thrombin-antithrombin III, fibrin monomers) in patients with mechanical heart valves, CABG, or DVT/PE?
Population
180 patients receiving stable oral anticoagulation treatment, consisting of 60 patients with mechanical…
Comparison
Different levels of oral anticoagulation as… vs Healthy individuals and comparisons across…
Design
Cross-sectional
Authors
Loading...
May support prothrombin fragment 1+2 as a thrombin activity index during anticoagulation; leaves open its added value beyond INR in mechanical valves or thromboembolism.
Does the intensity of oral anticoagulation (measured by INR) correlate with markers of coagulation activation (prothrombin fragment 1+2, thrombin-antithrombin III, fibrin monomers) in patients with mechanical heart valves, CABG, or DVT/PE?
Prothrombin fragment 1 + 2 is a suitable laboratory index of low thrombin activity during oral anticoagulation therapy, as it inversely correlates with INR across different patient populations.
Wersch et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: