Why the study?
How do different intensities of oral anticoagulation affect markers of coagulation activation and reactive fibrinolysis in patients with mechanical heart valve prostheses?
Population
60 patients with mechanical heart valve prosthesis
Comparison
Oral anticoagulation at different intensities vs Comparison across the three different INR…
Design
Cross-sectional
Authors
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May signal increased hemorrhagic risk despite thrombin suppression in mechanical valve patients; leaves open whether D-dimer monitoring could refine anticoagulation intensity.
How do different intensities of oral anticoagulation affect markers of coagulation activation and reactive fibrinolysis in patients with mechanical heart valve prostheses?
In patients with mechanical heart valves, oral anticoagulation adequately suppresses thrombin activity but leads to unexpectedly high D-dimer levels, suggesting enhanced fibrin degradation that may contribute to hemorrhagic risk.
Wersch et al. (1992) studied this question.
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