Key result
Intracoronary bolus infusion of hypertonic saline solution in anaesthetized pigs caused a steady-state increase in coronary blood flow dependent on the release of EDRF.
Why the study?
Does intracoronary bolus infusion of hypertonic saline solution increase coronary blood flow in anaesthetized pigs?
Does intracoronary bolus infusion of hypertonic saline solution increase coronary blood flow in anaesthetized pigs?
Intracoronary hypertonic saline induces coronary vasodilation in a porcine model via an endothelium-derived relaxing factor (EDRF)-dependent mechanism.
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Hypertonic saline may promote coronary vasodilation via EDRF in pigs; leaves open translation to human physiology or therapy.
Vacca et al. (1996) studied Anaesthetized pigs (n=16). Hypertonic saline solution vs. Normal saline solution (0.9%) was evaluated on Left circumflex coronary blood flow. Intracoronary bolus infusion of hypertonic saline solution in anaesthetized pigs caused a steady-state increase in coronary blood flow dependent on the release of EDRF.
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