Answers are grounded in this paper and cite their sources.
Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.
No takes yet. Share an insight, caveat, or question.
Bruni et al. (1979) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: