Key result
Sevoflurane and propofol during CABG are linked to ~27% lower cardiac index in elderly patients.
Why the study?
Does a combination of sevoflurane and propofol affect hemodynamic parameters in elderly patients undergoing coronary artery bypass graft?
Observational (n=36)
No
Does a combination of sevoflurane and propofol affect hemodynamic parameters in elderly patients undergoing coronary artery bypass graft?
The combination of sevoflurane and propofol during CABG in elderly patients depresses myocardial contractility and coronary perfusion.
Answers are grounded in this paper and cite their sources.
Should not yet change anesthetic regimens in elderly CABG; hypothesis-generating for contractility effects and requires randomized confirmation.
The hemodynamic parameters using balanced anesthesia based on propofol and sevoflurane in elderly patients are studied. The aim of the present work was to study the parameters of systemic hemodynamics in anesthesiology maintenance of operations coronary artery bypass graft in elderly and senile patients.Methods. A total of 36 patients from 65 to 83 years who underwent myocardial revascularization using sevoflurane and propofol are examined. The indicators that reflect the functional state of the heart, coronary blood flow and systemic hemodynamics in general are registered.Results. For combining use of sevoflurane and propofol it is observed a decrease of stroke work index of left ventricular, stroke index, ejection fraction, which was accompanied by decrease in the degree of shortening of the anteroposterior size of the left ventricle during systole and a decrease in the index of general peripheral resistance. Coronary perfusion index also tended to decrease.Conclusion. Using a combination of sevoflurane and propofol during coronary artery bypass graft in elderly and senile patients it is recorded a decrease of contractile ability of the myocardium and coronary blood flow depletion, which was connected with vasodilatation and decrease of coronary perfusion
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А Н Дружина (2015) conducted an observational in Ischemic heart disease (n=36). Sevoflurane and propofol vs. Baseline (pre-induction) was evaluated on Cardiac index at induction (L/min/m2) (26.66% decrease, p=<0.05). The combination of sevoflurane and propofol during coronary artery bypass grafting in elderly patients significantly decreased myocardial contractility, including a 26.66% reduction in cardiac index, and depleted coronary blood flow.
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