Key result
Sumatriptan administration significantly increased total electromechanical systole (95% CI 8-36 ms, P<0.0001) and mean arterial pressure (95% CI 9-14 mmHg, P=0.0001).
Why the study?
Does sumatriptan affect systolic time intervals and mean arterial pressure in patients undergoing diagnostic cardiac catheterization?
Does sumatriptan affect systolic time intervals and mean arterial pressure in patients undergoing diagnostic cardiac catheterization?
p-value: p=<0.0001
Systolic time intervals can serve as a non-invasive marker for the haemodynamic effects of sumatriptan, reflecting changes in afterload.
AIMS: This study assessed the use of systolic time intervals (STI) as a potential non-invasive marker of the haemodynamic effects of sumatriptan, a 5HT1 receptor agonist. METHODS: Twenty-six patients undergoing diagnostic cardiac catheterization participated. STIs were derived from haemodynamic pressure tracings at baseline, following placebo injection and following either subcutaneous (n=18) or intravenous injection (n=8) of sumatriptan. RESULTS: Sumatriptan (i.v. or s.c.) was associated with significant increases in mean arterial pressure (95% C.I. 9,14mmHg, P=0.0001), total electromechanical systole (95% C.I.8,36ms, P<0.0001), pre-ejection period (95%C.I. 8,21ms, P=0.0001) and left ventricular ejection time (95% C.I. 2,12ms, P=0.004). Conclusion STI responses were consistent with sumatriptan-induced changes in afterload. In summary, the measurement of STIs is a potential non-invasive method of investigating the influence of serotonergic compounds on the cardiovascular system.
No takes yet. Share an insight, caveat, or question.
Hood et al. (1999) studied Patients undergoing diagnostic cardiac catheterization (n=26). Sumatriptan vs. Placebo was evaluated on Total electromechanical systole (95% CI 8-36, p=<0.0001). Sumatriptan administration significantly increased total electromechanical systole (95% CI 8-36 ms, P<0.0001) and mean arterial pressure (95% CI 9-14 mmHg, P=0.0001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: