Systolic time intervals as possible predictors of pressure response to sustained beta-adrenergic blockade in arterial hypertension. A within-patient, placebo-controlled study.
Why the study?
Do systolic time intervals predict blood pressure response to metoprolol in hypertensive outpatients?
Structured PICO
Do systolic time intervals predict blood pressure response to metoprolol in hypertensive outpatients?
P
Population
20 hypertensive outpatients, WHO Stage 1 or 2
I
Intervention
Slow-release metoprolol 200 mg once daily for 4 weeks
C
Comparator
Matched placebo for 4 weeks
O
Outcome
Blood pressure and systolic time intervals (STI) at rest and during isometric exercise (IHG)surrogate
Systolic time intervals, specifically the PEP/LVET ratio, may help predict the magnitude of blood pressure reduction in response to beta-blocker therapy in patients with mild-to-moderate hypertension.
Authors
Discussion
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Implication
Baseline pre-ejection period assessment may guide metoprolol selection in hypertension; extends systolic time interval predictors to randomized beta-blocker response.
Cite This Study
Verdecchia et al. (1983) studied this question.