Zidoyudine-Induced Hepatotoxicity

Brief Reports1 January 1989Zidoyudine-Induced HepatotoxicityGary Dubin, MD, Michael N. Braffman, MDGary Dubin, MDSearch for more papers by this author, Michael N. Braffman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-1-85 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptZidovudine (3′-azido-3′-deoxythymidine) has been shown to decrease the frequency of opportunistic infections, increase the number of CD4 cells, and decrease mortality in patients infected with the human immunodeficiency virus (HIV) over a 6-month study period (1). Adverse reactions to zidovudine are common and include bone marrow suppression, nausea, insomnia, myalgia, and reduction of vitamin B12(2). The need to discontinue the drug for reasons other than hematologic toxicity is uncommon. We report a patient who experienced acute cholestatic hepatitis on initial exposure to and rechallenge with zidovudine and, as a result, was unable to receive further therapy with the drug....References1. FischlRichmanGrieco MDM. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and the AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med. 1987;317:185-91. CrossrefMedlineGoogle Scholar2. RichmanFischlGrieco DMM. The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. N Engl J Med. 1987;317:192-7. CrossrefMedlineGoogle Scholar3. MelamedMullerGoldCampbellKleinbergArmstrong ARJSMD. Possible zidovudine-induced hepatotoxicity [Letter]. JAMA. 1987;258:2063. CrossrefMedlineGoogle Scholar4. SchneidermanArensonCelloMargarettenWeber DDJWT. Hepatic disease in patients with the acquired immune deficiency syndrome (AIDS). Hepatology. 1987;7:925-30. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Pennsylvania Hospital and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. For current author addresses, see end of text. 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