Key result
Inflammatory cytokines, shear stress, and cyclic stretch upregulate EDL mRNA in cultured human endothelial cells.
Population
Cultured human umbilical vein and coronary artery endothelial cells
Design
Preclinical
Authors
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Endothelial lipase may modulate atherosclerosis; hypothesis-generating and requires in vivo validation before any clinical consideration.
The highly regulated expression of endothelial-derived lipase by inflammatory cytokines and mechanical forces suggests it plays a role in modulating vessel wall lipid metabolism and atherosclerosis.
Hirata et al. (2000) studied Vascular disease. Inflammatory cytokines (TNF-alpha, IL-1beta), fluid shear stress, and cyclic stretch was evaluated on EDL mRNA levels. Inflammatory cytokines (TNF-alpha and IL-1beta), fluid shear stress, and cyclic stretch upregulated endothelial-derived lipase mRNA levels in cultured human endothelial cells.
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