What question did this study set out to answer?

To assess the diagnostic utility and clinical impact of contrast-enhanced ultrasound for characterizing high-risk indeterminate focal liver observations classified as LR-4 or LR-M on CT or MRI.

January 1, 2025RadiologyOpen Access

Contrast-enhanced US of High-Risk Indeterminate Focal Liver Observations Categorized as LR-4 or LR-M at CT/MRI

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Authors

ALAndrej Lyshchik CKCristina Kuon-Yeng TXTania Siu Xiao

Discussion

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Overview

Randomized trial shows contrast-enhanced ultrasound resolves indeterminate focal liver observations, indicating altered management in 40% of patients.

Key Points

To assess the diagnostic utility and clinical impact of contrast-enhanced ultrasound for characterizing high-risk indeterminate focal liver observations classified as LR-4 or LR-M on CT or MRI.
Interventional clinical trial (ClinicalTrials.gov: NCT03318380) evaluating contrast-enhanced ultrasound (CEUS) for indeterminate focal liver observations (N=68).
Observations previously designated as LR-4 or LR-M on CT or MRI were re-evaluated with CEUS, with subgroup focus on lesions measuring at least 20 mm.
CEUS correctly categorized indeterminate lesions into LR-5 hepatocellular carcinoma and LR-M non-hepatocellular malignancies.
CEUS led to management recommendation changes in 40% (27 of 68) of observations with 100% accuracy, demonstrating particularly high impact for lesions measuring at least 20 mm.

Cite This Study

Lyshchik et al. (2025) studied this question.

synapsesocial.com/papers/6aa4469b22af0bded4f43d18 https://doi.org/10.1148/radiol.240916

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January 1, 2025RadiologyOpen Access

Contrast-enhanced US of High-Risk Indeterminate Focal Liver Observations Categorized as LR-4 or LR-M at CT/MRI

View Full Paper

Ask AI

Bookmark

Authors

ALAndrej Lyshchik CKCristina Kuon-Yeng TXTania Siu Xiao

Discussion

Member takes

Overview

Randomized trial shows contrast-enhanced ultrasound resolves indeterminate focal liver observations, indicating altered management in 40% of patients.

Key Points

To assess the diagnostic utility and clinical impact of contrast-enhanced ultrasound for characterizing high-risk indeterminate focal liver observations classified as LR-4 or LR-M on CT or MRI.
Interventional clinical trial (ClinicalTrials.gov: NCT03318380) evaluating contrast-enhanced ultrasound (CEUS) for indeterminate focal liver observations (N=68).
Observations previously designated as LR-4 or LR-M on CT or MRI were re-evaluated with CEUS, with subgroup focus on lesions measuring at least 20 mm.
CEUS correctly categorized indeterminate lesions into LR-5 hepatocellular carcinoma and LR-M non-hepatocellular malignancies.
CEUS led to management recommendation changes in 40% (27 of 68) of observations with 100% accuracy, demonstrating particularly high impact for lesions measuring at least 20 mm.

Cite This Study

Lyshchik et al. (2025) studied this question.

synapsesocial.com/papers/6aa4469b22af0bded4f43d18 https://doi.org/10.1148/radiol.240916

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