What is the clinical evidence from this study?

Study design: Other. Population: Marfan syndrome. Intervention: Decorin (DCN) gene expression. Primary outcome: DCN mRNA levels and chromosomal location.

May 14, 2008Cytogenetics and Cell Genetics

Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN)

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Key result

Decorin gene maps to chromosome 12q21-q22 and expresses high mRNA levels in aorta and smooth muscle.

Authors

LPLea PulkkinenUniversity of Jyväskylä TATiina AlitaloUniversity of Helsinki TKTom KrusiusFinnish Red Cross

Discussion

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Implication

Decorin expression patterns support matrix biology studies; leaves open its roles in vascular or fibrotic disease.

PICO

Population

Marfan syndrome

Exposure / Comparator

Decorin (DCN) gene expression

Primary Outcome

DCN mRNA levels and chromosomal location

Cite This Study

Pulkkinen et al. (2008) studied Marfan syndrome. Decorin (DCN) gene expression was evaluated on DCN mRNA levels and chromosomal location. High mRNA levels of decorin were detected in aorta, lung, skin, kidney, smooth muscle, and placenta, and the gene was mapped to chromosome 12q21-q22.

synapsesocial.com/papers/6aa447c5d5ccfe0ebfb7311e https://doi.org/10.1159/000133314

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Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN)

Discussion

Member takes

Implication

PICO

Cite This Study

Expression of decorin in human tissues and cell lines and defined chromosomal assignment of the gene locus (DCN)

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider