Hematin-lnduced Hemolysis in Acute Porphyria

Letters and Corrections1 December 1984Hematin-lnduced Hemolysis in Acute PorphyriaJOHN M. PETERSEN, D.O., CLAUS A. PIERACH, M.D.JOHN M. PETERSEN, D.O., CLAUS A. PIERACH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-877_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although complications associated with the use of hematin have been rare, we report a case of hematin-related hemolysis in a woman with severe acute intermittent porphyria.A 32-year-old woman who had had symptomatic acute intermittent porphyria for 18 months presented with her fourth monthly episode of Porphyric neuropathy. She had severe, non-localized, lower abdominal pain requiring high-dose narcotics; resting tachycardia; fever without leukocytosis; hypertension (170/120 mm Hg); depression; urinary retention; the syndrome of inappropriate diuretic hormone secretion; and quadriparesis. An electromyogram 1 year before had shown a mild median neuropathy of the right hand with some delay...References1. LAMONFRYKHOLMHESSTSCHUDY JBRD. Hematin therapy for acute porphyria. Medicine. 1979;58:252-69. CrossrefMedlineGoogle Scholar2. DHARBOSSENMAIERCARDINALPETRYKAWATSON GIRZC. Transitory renal failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission. Acta Med Scand. 1978;203:437-43. CrossrefMedlineGoogle Scholar3. MORRISDUDLEYPEARSON DMR. Coagulopathy associated with hematin treatment for acute intermittent porphyria. Ann Intern Med. 1981;95:700-1. LinkGoogle Scholar4. GLUECKGREENCOHENTSAO RDIC. Hematin: unique effects on hemostasis. Blood. 1983;61:243-9. CrossrefMedlineGoogle Scholar5. CHOUFITCH AC. Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. J Clin Invest. 1980;66:856-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDifferential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrinFerriporphyrins and endothelium: a 2-edged sword—promotion of oxidation and induction of cytoprotectantsManagement of Acute Attacks in the PorphyriasPorphyries hépatiques : stratégies diagnostiques et thérapeutiquesThe PorphyriasHeme in the treatment of heme deficiency statesDrug-induced red cell dyscrasiasReferences 1 December 1984Volume 101, Issue 6Page: 877-878KeywordsAbdominal painDiureticsElectromyographyFeversHormonesHypertensionLeukocytosisNeuropathyPorphyriaTachycardia Issue Published: 1 December 1984 PDF DownloadLoading ...