Key result
Anastomotic leakage is linked to worse overall survival after left-sided colorectal cancer surgery.
Why the study?
Anastomotic leakage significantly impairs short-term outcomes, but its impact on long-term outcomes remains unclear.
What are the risk factors for anastomotic leakage and its impact on long-term survival in patients undergoing left-sided colorectal cancer surgery?
Comparison
Patients with vs without anastomotic leakage
Authors
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AL impairs long-term DFS/OS after left-sided resection; observational data leave open whether preventing AL improves survival.
Cohort (n=900)
Yes
What are the risk factors for anastomotic leakage and its impact on long-term survival in patients undergoing left-sided colorectal cancer surgery?
p-value: p=0.001 (sigmoid) and 0.014 (rectal)
Anastomotic leakage after left-sided colorectal surgery is associated with specific risk factors (ASA score, male sex, CCI score, T stage) and significantly impairs long-term survival.
Kryžauskas et al. (2020) conducted a cohort in Left-sided colorectal cancer (n=900). Anastomotic leakage vs. No anastomotic leakage was evaluated on Overall survival (p=0.001 (sigmoid) and 0.014 (rectal)). Anastomotic leakage significantly impaired overall survival in patients undergoing sigmoid (p=0.001) and rectal (p=0.014) surgery for left-sided colorectal cancer.
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