Key result
Improved vWF assay using DMSO-frozen platelets shows excellent correlation with Factor VIII antigen.
Design
Other
Authors
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Enables stable von Willebrand factor assays in labs; leaves open clinical validation before routine use.
The study describes a stable, improved assay for von Willebrand factor using DMSO-frozen platelets that correlates excellently with Factor VIII antigen.
Head et al. (1979) studied this question. Improved assay for von Willebrand factor utilizing 4% DMSO to freeze formalin-fixed washed platelets vs. Factor VIII antigen (VIIIAg) measured by electroimmunodiffusion was evaluated on Correlation between VIIIVWF measured by the new system and Factor VIII antigen (VIIIAg). An improved assay for von Willebrand factor using DMSO-frozen platelets showed excellent correlation with Factor VIII antigen measured by electroimmunodiffusion.
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