Key result
Administration of LMWH and prednisolone did not significantly improve clinical pregnancy rates compared to control (29.8% vs 19%, P=0.175) in women with repeated implantation failures.
Why the study?
Does the combined administration of LMWH and prednisolone improve clinical pregnancy rates in women with repeated implantation failures undergoing IVF/ICSI?
Cohort (n=115)
Does the combined administration of LMWH and prednisolone improve clinical pregnancy rates in women with repeated implantation failures undergoing IVF/ICSI?
Absolute Event Rate: 29.8% vs 19%
p-value: p=0.175
The combined use of LMWH and prednisolone does not significantly improve clinical pregnancy rates in women with repeated implantation failures.
Does not support routine LMWH-prednisolone use in repeated implantation failure; leaves open benefit pending RCTs.
Conflicting results exist for low molecular weight heparin (LMWH) and prednisolone when tested as separate adjuncts for the improvement of the clinical outcomes in patients with repeated implantation failures (RIF) undergoing IVF/ICSI treatment. Through a cohort study, we evaluated the combined effect of both drugs on pregnancy parameters in 115 women with RIF. Clinical pregnancy rate was the primary end point while the sample size was calculated through the results of a pilot study. Clinical and IVF cycle characteristics were also compared between the groups. Baseline and cycle characteristics were comparable between groups. Biochemical and clinical pregnancy rates were similar in both groups [23/57 (40.4%) vs. 14/58 (24.1%), and 17/57 (29.8%) vs. 11/58 (19%), p = .063, and .175, respectively]. Similarly, miscarriage rates were comparable between the groups (35.7% vs. 34.8%), as well as live birth rates [15/57 (26.3%) vs. 9/58 (15.5%), p = .154]. In conclusion, the administration of LMWH with prednizolone in subfertile women with RIF seems not to improve clinical pregnancy rates, but a full-scaled RCT would definitely be more accurate.
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Siristatidis et al. (2017) conducted a cohort in Repeated implantation failures (RIF) (n=115). Low molecular weight heparin (LMWH) and prednisolone vs. Unexposed/control group was evaluated on Clinical pregnancy rate (p=0.175). Administration of LMWH and prednisolone did not significantly improve clinical pregnancy rates compared to control (29.8% vs 19%, P=0.175) in women with repeated implantation failures.
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