Key result
LMWH plus prednisolone links to better IVF pregnancy and live birth rates versus LMWH alone.
Why the study?
Does the coadministration of LMWH and prednisolone improve pregnancy outcomes in women with previously failed IVF/ICSI cycles?
Does the coadministration of LMWH and prednisolone improve pregnancy outcomes in women with previously failed IVF/ICSI cycles?
The combination of LMWH and prednisolone may improve pregnancy outcomes in women with previously failed IVF/ICSI cycles, warranting further randomized trials.
Associated with improved outcomes in failed IVF cycles; leaves open causal benefit and safety pending RCTs.
Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles. Fifteen women constituted the study group, and were compared with 19 women receiving LMWH alone and another 18 women with no drugs. Our finding that the combination of the two drugs produced positive differences in terms of embryo quality, pregnancy and live birth rates points to the necessity for adequately powered randomized trials.
No takes yet. Share an insight, caveat, or question.
Siristatidis et al. (2013) studied previously failed IVF/ICSI cycles (n=52). Low molecular weight heparin (LMWH) and prednisolone vs. LMWH alone or no drugs was evaluated on Embryo quality, pregnancy and live birth rates. Coadministration of LMWH and prednisolone produced positive differences in embryo quality, pregnancy, and live birth rates compared to LMWH alone or no drugs in women with failed IVF/ICSI cycles.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: