Key result
CPAP or sleep apnea surgery linked to ~32% fewer non-dipping blood pressure patterns and lower Angiotensin II.
Why the study?
Does CPAP or surgical treatment improve plasma angiotensin II levels and circadian blood pressure rhythm in hypertensive patients with sleep apnea syndrome?
Cohort (n=180)
Does CPAP or surgical treatment improve plasma angiotensin II levels and circadian blood pressure rhythm in hypertensive patients with sleep apnea syndrome?
p-value: p=<0.05
Treatment of sleep apnea syndrome with CPAP or surgery in hypertensive patients significantly reduces plasma angiotensin II levels and improves circadian blood pressure rhythms.
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May support adjunctive sleep apnea treatment for BP dipping in hypertension; hypothesis-generating, requires RCTs before practice change.
Wang et al. (2011) conducted a cohort in Essential hypertension with sleep apnea syndrome (n=180). CPAP or surgical treatment vs. Baseline (before treatment) was evaluated on Plasma angiotensin II concentration and incidence of non-dipper blood pressure curve (p=<0.05). CPAP or surgical treatment in hypertensive patients with moderate-severe sleep apnea reduced plasma Angiotensin II from 18.73 to 15.03 ng/mL and non-dipper blood pressure from 58.3% to 39.6% (P<0.05).
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