Key result
Bovine red cells maintain mechanical and energetic stability in isolated rabbit hearts for ~60 minutes.
Population
Isolated rabbit heart perfused with a suspension of bovine red cells in Krebs-Henseleit buffer
Comparison
Perfusion over 120 minutes vs Baseline (control values)
Design
Preclinical
Follow-up
120 minutes
Authors
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Supports short-term use of this preparation in isolated-heart research; leaves open questions on stability beyond 60 minutes.
p-value: p=NS
The isolated bovine red cell-perfused rabbit heart preparation maintains mechanical and energetic stability for at least 60 minutes, validating its use in short-term physiological studies.
Yaku et al. (1991) studied Isolated rabbit heart preparation. Perfusion with bovine red cells in Krebs-Henseleit buffer vs. Baseline/control values was evaluated on Mechanical and energetic stability (Emax, slope, and VO2 intercept of the VO2-PVA relation) (p=NS). In isolated rabbit hearts perfused with bovine red cells, mechanical and energetic parameters remained stable for at least 60 minutes, though the linear fit of the VO2-PVA relation decreased after 90 minutes.
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