Key result
Proximal lesions occur most frequently in severe CAD, affecting ~66% of stenosed autopsy vessels.
Observational (n=102)
Absolute Event Rate: 66% vs 42%
p-value: p=<0.001
Proximal coronary atherosclerotic lesions are significantly more common than distal lesions, and traditional cardiac risk factors do not preferentially increase the prevalence of distal disease.
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Proximal predominance in severe CAD warrants angiographic focus; leaves open whether risk factors alter segmental distribution in vivo.
Hochman et al. (1988) conducted an observational in Coronary artery disease (n=102). Coronary artery segment location (proximal) vs. Mid and distal segments was evaluated on Prevalence of disease in vessels with ≥75% stenosis (p=<0.001). In autopsy hearts with coronary artery disease, proximal lesions were significantly more frequent (66%) than mid (42%) or distal (16%) lesions in vessels with ≥75% stenosis (p<0.001).
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