Preclinical study demonstrates high analgesic activity of isopulegol-derived octahydrochromenes in animal models, suggesting novel therapeutic leads for pain management.
A number of new derivatives of octahydro-2H-chromene based on monoterpenoid (–)-isopulegol has been synthesized. The composition and structure of the products have been established using NMR spectroscopy, high-resolution mass spectrometry, and X-ray diffraction analysis. It has been shown that the majority of obtained compounds show high analgesic activity in vivo. (4S)‑Diastereomers of morpholinoacetamide derivatives of octahydro-2H-chromene showed the highest efficiency in both tests (acetic acid-induced writhing test and hot plate test).
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Ли-Жуланов et al. (2023) studied this question.
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